4AWG

Influenza strain pH1N1 2009 polymerase subunit PA endonuclease in complex with diketo compound 3

Summary for 4AWG

• Entry DOI: 10.2210/pdb4awg/pdb
• Related: 4AVG 4AVL 4AVQ 4AWF 4AWH 4AWK 4AWM
• Descriptor: POLYMERASE PA, SULFATE ION, (2Z)-4-[(3S)-1-benzyl-3-(4-chlorobenzyl)piperidin-3-yl]-2-hydroxy-4-oxobut-2-enoic acid, ... (5 entities in total)
• Functional Keywords: hydrolase-inhibitor complex, hydrolase, manganese-dependent, hydrolase/inhibitor
• Biological source: INFLUENZA A VIRUS
• Total number of polymer chains: 4
• Total formula weight: 99197.13

Authors

Kowalinski, E.,Zubieta, C.,Wolkerstorfer, A.,Szolar, O.H.,Ruigrok, R.W.,Cusack, S. (deposition date: 2012-06-03, release date: 2012-08-22, Last modification date: 2023-12-20)

• Primary citation: Kowalinski, E.,Zubieta, C.,Wolkerstorfer, A.,Szolar, O.H.,Ruigrok, R.W.,Cusack, S.; Structural Analysis of Specific Metal Chelating Inhibitor Binding to the Endonuclease Domain of Influenza Ph1N1 (2009) Polymerase.; Plos Pathog., 8:2831-, 2012; PubMed: 22876177; DOI: 10.1371/JOURNAL.PPAT.1002831

Experimental method

X-RAY DIFFRACTION (2.6 Å)