4AW6

Crystal structure of the human nuclear membrane zinc metalloprotease ZMPSTE24 (FACE1)

4AW6 の概要

分子名称CAAX PRENYL PROTEASE 1 HOMOLOG, ZINC ION, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE (3 entities in total)
機能のキーワードhydrolase, m48 peptidase, integral membrane protein, prelamin a processing, ageing, progeria
由来する生物種HOMO SAPIENS (HUMAN)
細胞内の位置Endoplasmic reticulum membrane ; Multi-pass membrane protein  O75844
ポリマー鎖数4
分子量合計226248.25
構造登録者
主引用文献
Quigley, A.,Dong, Y.Y.,Pike, A.C.W.,Dong, L.,Shrestha, L.,Berridge, G.,Stansfeld, P.J.,Sansom, M.S.P.,Edwards, A.M.,Bountra, C.,von Delft, F.,Bullock, A.N.,Burgess-Brown, N.A.,Carpenter, E.P.
The Structural Basis of Zmpste24-Dependent Laminopathies.
Science, 339:1604-, 2013
PubMed: 23539603 (主引用文献が同じPDBエントリー)
DOI: 10.1126/SCIENCE.1231513
MImport into Mendeley
実験手法
X-RAY DIFFRACTION (3.4 Å)
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構造検証レポート

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.27720.2%2.4%4.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
検証レポート(詳細版)をダウンロード