4ARK

CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN MAP KINASE KINASE 1 (MEK1) IN COMPLEX WITH A SMALL MOLECULE INHIBITOR AND ADP

Summary for 4ARK

Entry DOI	10.2210/pdb4ark/pdb
Related	1S9J 4AN2 4AN3 4AN9 4ANB
Descriptor	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... (5 entities in total)
Functional Keywords	transferase, kinase, inhibitor
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Cytoplasm, cytoskeleton, microtubule organizing center, centrosome : Q02750
Total number of polymer chains	1
Total formula weight	38860.34
Authors	Hartung, I.V.,Hitchcock, M.,Puehler, F.,Neuhaus, R.,Scholz, A.,Hammer, S.,Petersen, K.,Siemeister, G.,Brittain, D.,Hillig, R.C. (deposition date: 2012-04-24, release date: 2013-03-06, Last modification date: 2023-12-20)
Primary citation	Hartung, I.V.,Hitchcock, M.,Puehler, F.,Neuhaus, R.,Scholz, A.,Hammer, S.,Petersen, K.,Siemeister, G.,Brittain, D.,Hillig, R.C. Optimization of Allosteric Mek Inhibitors - Part 1: Venturing Into Unexplored Sar Territories Bioorg.Med.Chem.Lett., 23:2384-, 2013 Cited by PubMed: 23474388 DOI: 10.1016/J.BMCL.2013.02.028 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation