4AOY

Open CtIDH. The complex structures of Isocitrate dehydrogenase from Clostridium thermocellum and Desulfotalea psychrophila, support a new active site locking mechanism

Summary for 4AOY

Entry DOI	10.2210/pdb4aoy/pdb
Related	4AOU 4AOV
Descriptor	ISOCITRATE DEHYDROGENASE [NADP] (2 entities in total)
Functional Keywords	oxidoreductase, temperature adaptation, thermophilic, psychrophilic, nadp+ selectivity, domain movements
Biological source	CLOSTRIDIUM THERMOCELLUM
Total number of polymer chains	4
Total formula weight	183368.80
Authors	Leiros, H.-K.S.,Fedoy, A.-E.,Leiros, I.,Steen, I.H. (deposition date: 2012-03-30, release date: 2012-04-25, Last modification date: 2024-05-08)
Primary citation	Leiros, H.K.,Fedoy, A.E.,Leiros, I.,Steen, I.H. The complex structures of isocitrate dehydrogenase from Clostridium thermocellum and Desulfotalea psychrophila suggest a new active site locking mechanism. Febs Open Bio, 2:159-172, 2012 Cited by PubMed: 23650595 DOI: 10.1016/j.fob.2012.06.003 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.35 Å)

Structure validation