4ANS

Structure of L1196M,G1269A Double Mutant Anaplastic Lymphoma Kinase in Complex with Crizotinib

Summary for 4ANS

• Entry DOI: 10.2210/pdb4ans/pdb
• Related: 4ANL 4ANQ 4AOI
• Descriptor: ALK TYROSINE KINASE RECEPTOR, 3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)pyridin-2-amine (3 entities in total)
• Functional Keywords: transferase
• Biological source: HOMO SAPIENS (HUMAN)
• Total number of polymer chains: 1
• Total formula weight: 39078.53

Authors

McTigue, M.,Deng, Y.,Liu, W.,Brooun, A. (deposition date: 2012-03-22, release date: 2013-03-27, Last modification date: 2023-12-20)

• Primary citation: Mctigue, M.,Deng, Y.,Liu, W.,Brooun, A.; Structure of L1196M,G1269A Double Mutant Anaplastic Lymphoma Kinase in Complex with Crizotinib; To be Published,

Experimental method

X-RAY DIFFRACTION (1.85 Å)