4AN1
PROLYL OLIGOPEPTIDASE FROM PORCINE BRAIN WITH A COVALENTLY BOUND INHIBITOR IC-4
Summary for 4AN1
Entry DOI | 10.2210/pdb4an1/pdb |
Related | 1E5T 1E8M 1E8N 1H2W 1H2X 1H2Y 1H2Z 1O6F 1O6G 1QFM 1QFS 1UOO 1UOP 1UOQ 1VZ2 1VZ3 2XDW 4AMY |
Descriptor | PROLYL ENDOPEPTIDASE, (2S)-N-benzyl-2-({(2S)-2-[(1R)-1,2-dihydroxyethyl]pyrrolidin-1-yl}carbonyl)pyrrolidine-1-carboxamide, GLYCEROL, ... (4 entities in total) |
Functional Keywords | alpha/beta-hydrolase, amnesia, beta-propeller, hydrolase |
Biological source | SUS SCROFA (PIG) |
Cellular location | Cytoplasm: P23687 |
Total number of polymer chains | 1 |
Total formula weight | 81594.15 |
Authors | Kaszuba, K.,Rog, T.,Danne, R.,Canning, P.,Fulop, V.,Juhasz, T.,Szeltner, Z.,St-Pierre, J.F.,Garcia-Horsman, A.,Mannisto, P.T.,Karttunen, M.,Hokkanen, J.,Bunker, A. (deposition date: 2012-03-14, release date: 2012-05-16, Last modification date: 2023-12-20) |
Primary citation | Kaszuba, K.,Rog, T.,Danne, R.,Canning, P.,Fulop, V.,Juhasz, T.,Szeltner, Z.,St-Pierre, J.F.,Garcia-Horsman, A.,Mannisto, P.T.,Karttunen, M.,Hokkanen, J.,Bunker, A. Molecular Dynamics, Crystallography and Mutagenesis Studies on the Substrate Gating Mechanism of Prolyl Oligopeptidase. Biochimie, 94:1398-, 2012 Cited by PubMed: 22484394DOI: 10.1016/J.BIOCHI.2012.03.012 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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