4AMY

PROLYL OLIGOPEPTIDASE FROM PORCINE BRAIN WITH A COVALENTLY BOUND INHIBITOR IC-1

Summary for 4AMY

Entry DOI	10.2210/pdb4amy/pdb
Related	1E5T 1E8M 1E8N 1H2W 1H2X 1H2Y 1H2Z 1O6F 1O6G 1QFM 1QFS 1UOO 1UOP 1UOQ 1VZ2 1VZ3 2XDW 4AMZ 4AN0 4AN1
Descriptor	PROLYL ENDOPEPTIDASE, 1-[(2R,5S)-2-tert-butyl-5-({(2S)-2-[(1R)-1,2-dihydroxyethyl]pyrrolidin-1-yl}carbonyl)pyrrolidin-1-yl]-4-phenylbutan-1-one, GLYCEROL, ... (4 entities in total)
Functional Keywords	alpha-beta-hydrolase, amnesia, beta-propeller, hydrolase
Biological source	SUS SCROFA (PIG)
Cellular location	Cytoplasm: P23687
Total number of polymer chains	1
Total formula weight	81571.21
Authors	Kaszuba, K.,Rog, T.,Danne, R.,Canning, P.,Fulop, V.,Juhasz, T.,Szeltner, Z.,St-Pierre, J.F.,Garcia-Horsman, A.,Mannisto, P.T.,Karttunen, M.,Hokkanen, J.,Bunker, A. (deposition date: 2012-03-14, release date: 2012-05-16, Last modification date: 2023-12-20)
Primary citation	Kaszuba, K.,Rog, T.,Danne, R.,Canning, P.,Fulop, V.,Juhasz, T.,Szeltner, Z.,St-Pierre, J.F.,Garcia-Horsman, A.,Mannisto, P.T.,Karttunen, M.,Hokkanen, J.,Bunker, A. Molecular Dynamics, Crystallography and Mutagenesis Studies on the Substrate Gating Mechanism of Prolyl Oligopeptidase. Biochimie, 94:1398-, 2012 Cited by PubMed: 22484394 DOI: 10.1016/J.BIOCHI.2012.03.012 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation