4AKM

Crystal structure of the human lysosome-associated membrane protein LAMP-3 (aka DC-LAMP)

4AKM の概要

• エントリーDOI: 10.2210/pdb4akm/pdb
• 分子名称: LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEIN 3, IRIDIUM (III) ION, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• 機能のキーワード: membrane protein, glycosylation, beta prism
• 由来する生物種: HOMO SAPIENS (HUMAN)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 38524.70

構造登録者

Krausze, J.,Wilke, S.,Buessow, K. (登録日: 2012-02-24, 公開日: 2012-08-15, 最終更新日: 2024-10-09)

主引用文献

Wilke, S.,Krausze, J.,Bussow, K.
Crystal Structure of the Conserved Domain of the Dc Lysosomal Associated Membrane Protein: Implications for the Lysosomal Glycocalyx.
Bmc Biol., 10:62-, 2012

PubMed Abstract: The family of lysosome-associated membrane proteins (LAMP) comprises the multifunctional, ubiquitous LAMP-1 and LAMP-2, and the cell type-specific proteins DC-LAMP (LAMP-3), BAD-LAMP (UNC-46, C20orf103) and macrosialin (CD68). LAMPs have been implicated in a multitude of cellular processes, including phagocytosis, autophagy, lipid transport and aging. LAMP-2 isoform A acts as a receptor in chaperone-mediated autophagy. LAMP-2 deficiency causes the fatal Danon disease. The abundant proteins LAMP-1 and LAMP-2 are major constituents of the glycoconjugate coat present on the inside of the lysosomal membrane, the 'lysosomal glycocalyx'. The LAMP family is characterized by a conserved domain of 150 to 200 amino acids with two disulfide bonds.

PubMed: 22809326
DOI: 10.1186/1741-7007-10-62

実験手法

X-RAY DIFFRACTION (2.687 Å)