4AGU
CRYSTAL STRUCTURE OF THE HUMAN CDKL1 KINASE DOMAIN
Summary for 4AGU
Entry DOI | 10.2210/pdb4agu/pdb |
Descriptor | CYCLIN-DEPENDENT KINASE-LIKE 1, N-(5-{[(2S)-4-amino-2-(3-chlorophenyl)butanoyl]amino}-1H-indazol-3-yl)benzamide (3 entities in total) |
Functional Keywords | transferase, phospho-mimetic, kinase |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Cytoplasm : Q00532 |
Total number of polymer chains | 3 |
Total formula weight | 110264.42 |
Authors | Canning, P.,Sharpe, T.D.,Allerston, C.,Savitsky, P.,Pike, A.C.W.,Muniz, J.R.C.,Chaikuad, A.,Kuo, K.,Burgess-Brown, N.,Ayinampudi, V.,Zhang, Y.,Thangaratnarajah, C.,Ugochukwu, E.,Vollmar, M.,Krojer, T.,Weigelt, J.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,von Delft, F.,Knapp, S.,Bullock, A. (deposition date: 2012-01-31, release date: 2012-02-08, Last modification date: 2023-12-20) |
Primary citation | Canning, P.,Park, K.,Goncalves, J.,Li, C.,Howard, C.J.,Sharpe, T.D.,Holt, L.J.,Pelletier, L.,Bullock, A.N.,Leroux, M.R. CDKL Family Kinases Have Evolved Distinct Structural Features and Ciliary Function. Cell Rep, 22:885-894, 2018 Cited by PubMed: 29420175DOI: 10.1016/j.celrep.2017.12.083 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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