4AGU

CRYSTAL STRUCTURE OF THE HUMAN CDKL1 KINASE DOMAIN

4AGU の概要

• エントリーDOI: 10.2210/pdb4agu/pdb
• 分子名称: CYCLIN-DEPENDENT KINASE-LIKE 1, N-(5-{[(2S)-4-amino-2-(3-chlorophenyl)butanoyl]amino}-1H-indazol-3-yl)benzamide (3 entities in total)
• 機能のキーワード: transferase, phospho-mimetic, kinase
• 由来する生物種: HOMO SAPIENS (HUMAN)
• 細胞内の位置: Cytoplasm : Q00532
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 110264.42

構造登録者

Canning, P.,Sharpe, T.D.,Allerston, C.,Savitsky, P.,Pike, A.C.W.,Muniz, J.R.C.,Chaikuad, A.,Kuo, K.,Burgess-Brown, N.,Ayinampudi, V.,Zhang, Y.,Thangaratnarajah, C.,Ugochukwu, E.,Vollmar, M.,Krojer, T.,Weigelt, J.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,von Delft, F.,Knapp, S.,Bullock, A. (登録日: 2012-01-31, 公開日: 2012-02-08, 最終更新日: 2023-12-20)

• 主引用文献: Canning, P.,Park, K.,Goncalves, J.,Li, C.,Howard, C.J.,Sharpe, T.D.,Holt, L.J.,Pelletier, L.,Bullock, A.N.,Leroux, M.R.; CDKL Family Kinases Have Evolved Distinct Structural Features and Ciliary Function.; Cell Rep, 22:885-894, 2018; PubMed: 29420175; DOI: 10.1016/j.celrep.2017.12.083

実験手法

X-RAY DIFFRACTION (2.4 Å)