4AGD

CRYSTAL STRUCTURE OF VEGFR2 (JUXTAMEMBRANE AND KINASE DOMAINS) IN COMPLEX WITH SUNITINIB (SU11248) (N-2-diethylaminoethyl)-5-((Z)-(5- fluoro-2-oxo-1H-indol-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3- carboxamide)

4AGD の概要

• エントリーDOI: 10.2210/pdb4agd/pdb
• 関連するPDBエントリー: 1VR2 1Y6A 1Y6B 1YWN 2X1W 2X1X 2XIR 4AG8 4AGC 4ASD 4ASE
• 分子名称: VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2, N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carbo xamide (3 entities in total)
• 機能のキーワード: transferase, angiogenesis, nucleotide-binding, inhibitor, phosphorylation, transmembrane
• 由来する生物種: HOMO SAPIENS (HUMAN)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 40656.87

構造登録者

McTigue, M.,Deng, Y.,Ryan, K.,Brooun, A.,Diehl, W.,Stewart, A. (登録日: 2012-01-26, 公開日: 2012-09-26, 最終更新日: 2023-12-20)

• 主引用文献: Mctigue, M.,Murray, B.W.,Chen, J.H.,Deng, Y.,Solowiej, J.,Kania, R.S.; Molecular Conformations, Interactions, and Properties Associated with Drug Efficiency and Clinical Performance Among Vegfr Tk Inhibitors.; Proc.Natl.Acad.Sci.USA, 109:18281-, 2012; PubMed: 22988103; DOI: 10.1073/PNAS.1207759109

実験手法

X-RAY DIFFRACTION (2.81 Å)