4AF0
Crystal structure of cryptococcal inosine monophosphate dehydrogenase
Summary for 4AF0
| Entry DOI | 10.2210/pdb4af0/pdb |
| Descriptor | INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE, MYCOPHENOLIC ACID, INOSINIC ACID, ... (6 entities in total) |
| Functional Keywords | oxidoreductase, gtp biosynthesis, drug resistance |
| Biological source | CRYPTOCOCCUS NEOFORMANS More |
| Cellular location | Cytoplasm (By similarity): E3P6S0 E3P6S0 |
| Total number of polymer chains | 2 |
| Total formula weight | 120269.92 |
| Authors | Valkov, E.,Stamp, A.,Morrow, C.A.,Kobe, B.,Fraser, J.A. (deposition date: 2012-01-15, release date: 2012-10-24, Last modification date: 2023-12-20) |
| Primary citation | Morrow, C.A.,Valkov, E.,Stamp, A.,Chow, E.W.L.,Lee, I.R.,Wronski, A.,Williams, S.J.,Hill, J.M.,Djordjevic, J.T.,Kappler, U.,Kobe, B.,Fraser, J.A. De Novo GTP Biosynthesis is Critical for Virulence of the Fungal Pathogen Cryptococcus Neoformans Plos Pathog., 8:2957-, 2012 Cited by PubMed: 23071437DOI: 10.1371/JOURNAL.PPAT.1002957 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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