4AF0

Crystal structure of cryptococcal inosine monophosphate dehydrogenase

4AF0 の概要

• エントリーDOI: 10.2210/pdb4af0/pdb
• 分子名称: INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE, MYCOPHENOLIC ACID, INOSINIC ACID, ... (6 entities in total)
• 機能のキーワード: oxidoreductase, gtp biosynthesis, drug resistance
• 由来する生物種: CRYPTOCOCCUS NEOFORMANS; 詳細
• 細胞内の位置: Cytoplasm (By similarity): E3P6S0 E3P6S0
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 120269.92

構造登録者

Valkov, E.,Stamp, A.,Morrow, C.A.,Kobe, B.,Fraser, J.A. (登録日: 2012-01-15, 公開日: 2012-10-24, 最終更新日: 2023-12-20)

• 主引用文献: Morrow, C.A.,Valkov, E.,Stamp, A.,Chow, E.W.L.,Lee, I.R.,Wronski, A.,Williams, S.J.,Hill, J.M.,Djordjevic, J.T.,Kappler, U.,Kobe, B.,Fraser, J.A.; De Novo GTP Biosynthesis is Critical for Virulence of the Fungal Pathogen Cryptococcus Neoformans; Plos Pathog., 8:2957-, 2012; PubMed: 23071437; DOI: 10.1371/JOURNAL.PPAT.1002957

実験手法

X-RAY DIFFRACTION (2.2 Å)