4A6B

Stereoselective Synthesis, X-ray Analysis, and Biological Evaluation of a New Class of Lactam Based HIV-1 Protease Inhibitors

Summary for 4A6B

Entry DOI	10.2210/pdb4a6b/pdb
Related	1GNO 1WBK 1WBM 1ZPA 2CEJ 2CEM 4A4Q 4A6C
Descriptor	POL PROTEIN, METHYL ((S)-1-(2-([1,1'-BIPHENYL]-4-YLMETHYL)-2-(3-((3S,4S)-3-BENZYL-4-HYDROXY-1-((1S,2R)-2-HYDROXY-2,3-DIHYDRO-1H-INDEN-1-YL)-2-OXOPYRROLIDIN-3-YL)PROPYL)HYDRAZINYL)-3,3-DIMETHYL-1-OXOBUTAN-2-YL)CARBAMATE (3 entities in total)
Functional Keywords	hydrolase, gamma-butyrol-lactam
Biological source	HUMAN IMMUNODEFICIENCY VIRUS
Total number of polymer chains	2
Total formula weight	22284.22
Authors	Wu, X.,Ohrngren, P.,Joshi, A.A.,Trejos, A.,Persson, M.,Unge, J.,Arvela, R.K.,Wallberg, H.,Vrang, L.,Rosenquist, A.,Samuelsson, B.B.,Unge, J.,Larhed, M. (deposition date: 2011-11-01, release date: 2012-05-09, Last modification date: 2018-01-17)
Primary citation	Wu, X.,Ohrngren, P.,Joshi, A.A.,Trejos, A.,Persson, M.,Arvela, R.K.,Wallberg, H.,Vrang, L.,Rosenquist, A.,Samuelsson, B.B.,Unge, J.,Larhed, M. Synthesis, X-Ray Analysis, and Biological Evaluation of a New Class of Stereopure Lactam-Based HIV-1 Protease Inhibitors. J.Med.Chem., 55:2724-, 2012 Cited by PubMed: 22376008 DOI: 10.1021/JM201620T PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation