4A55

Crystal structure of p110alpha in complex with iSH2 of p85alpha and the inhibitor PIK-108

4A55 の概要

• エントリーDOI: 10.2210/pdb4a55/pdb
• 関連するPDBエントリー: 1A0N 1AZG 1H9O 1PBW 1PHT 1PIC 1PKS 1PKT 2IUG 2IUH 2IUI 2V1Y
• 分子名称: PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM, PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA, PIK-108 (3 entities in total)
• 機能のキーワード: transferase, oncogene, lipid kinase, membrane binding, cancer mutations, tumours, growth factor signalling, pi3-kinase inhibitor, non-atp competitive ligand binding site, structure-activity relationship, enzyme regulation
• 由来する生物種: MUS MUSCULUS (HOUSE MOUSE); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 162413.45

構造登録者

Hon, W.-C.,Berndt, A.,Williams, R.L. (登録日: 2011-10-24, 公開日: 2011-12-28, 最終更新日: 2023-12-20)

• 主引用文献: Hon, W.-C.,Berndt, A.,Williams, R.L.; Regulation of Lipid Binding Underlies the Activation Mechanism of Class Ia Pi3-Kinases.; Oncogene, 31:3655-, 2012; PubMed: 22120714; DOI: 10.1038/ONC.2011.532

実験手法

X-RAY DIFFRACTION (3.5 Å)