4A55
Crystal structure of p110alpha in complex with iSH2 of p85alpha and the inhibitor PIK-108
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM | polymer | 1096 | 128017.6 | 1 | UniProt (P42337) Pfam (PF02192) Pfam (PF00794) Pfam (PF00792) Pfam (PF00613) Pfam (PF00454) In PDB | MUS MUSCULUS (HOUSE MOUSE) | PI3-KINASE SUBUNIT ALPHA, PI3K-ALPHA, PI3KALPHA, PTDINS-3-KINASE SUBUNIT ALPHA, PHOSPHATIDYLINOSITOL-4\,5-BISPHOSPHATE 3-KINASE 110 KDA CATALYTIC SUBUNIT ALPHA, PTDINS-3-KINASE SUBUNIT P110-ALPHA, P110ALPHA, PHOSPHOINOSITIDE-3-KINASE CATALYTIC ALPHA POLYPEPTIDE, SERINE/THREONINE PROTEIN KINASE PIK3CA |
| 2 | B | PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA | polymer | 279 | 33667.0 | 1 | UniProt (P27986) Pfam (PF00017) Pfam (PF16454) In PDB | HOMO SAPIENS (HUMAN) | PI3-KINASE REGULATORY SUBUNIT ALPHA, PI3K REGULATORY SUBUNIT ALPHA, PTDINS-3-KINASE REGULATORY SUBUNIT ALPHA, PHOSPHATIDYLINOSITOL 3-KINASE 85 KDA REGULATORY SUBUNIT ALPHA, PI3-KINASE SUBUNIT P85-ALPHA, PTDINS-3-KINASE REGULATORY SUBUNIT P85-ALPHA |
| 3 | A | PIK-108 | non-polymer | 364.4 | 2 | Chemie (P08) |
Sequence modifications
A: 1 - 1068 (UniProt: P42337)
| PDB | External Database | Details |
|---|---|---|
| Met -27 | - | expression tag |
| Ser -26 | - | expression tag |
| Tyr -25 | - | expression tag |
| Tyr -24 | - | expression tag |
| His -23 | - | expression tag |
| His -22 | - | expression tag |
| His -21 | - | expression tag |
| His -20 | - | expression tag |
| His -19 | - | expression tag |
| His -18 | - | expression tag |
| Asp -17 | - | expression tag |
| Tyr -16 | - | expression tag |
| Asp -15 | - | expression tag |
| Ile -14 | - | expression tag |
| Pro -13 | - | expression tag |
| Thr -12 | - | expression tag |
| Thr -11 | - | expression tag |
| Glu -10 | - | expression tag |
| Asn -9 | - | expression tag |
| Leu -8 | - | expression tag |
| Tyr -7 | - | expression tag |
| Phe -6 | - | expression tag |
| Gln -5 | - | expression tag |
| Gly -4 | - | expression tag |
| Ala -3 | - | expression tag |
| Met -2 | - | expression tag |
| Asp -1 | - | expression tag |
| Pro 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 161684.6 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 728.9 | |
| All* | Total formula weight | 162413.4 |
