4A4Q
Stereoselective Synthesis, X-ray Analysis, and Biological Evaluation of a New Class of Lactam Based HIV-1 Protease Inhibitors
Summary for 4A4Q
Entry DOI | 10.2210/pdb4a4q/pdb |
Related | 1GNO 1WBK 1WBM 1ZPA 2CEJ 2CEM |
Descriptor | PROTEASE, methyl [(2S)-1-{2-(2-{(3R,4S)-3-benzyl-4-hydroxy-1-[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-2-oxopyrrolidin-3-yl}ethyl)-2-[4-(pyridin-4-yl)benzyl]hydrazinyl}-3,3-dimethyl-1-oxobutan-2-yl]carbamate (3 entities in total) |
Functional Keywords | hydrolase, gamma-butyrol-lactam, inhibitor |
Biological source | HUMAN IMMUNODEFICIENCY VIRUS (HIV-1) |
Total number of polymer chains | 2 |
Total formula weight | 22271.19 |
Authors | Wu, X.,Ohrngren, P.,Joshi, A.A.,Trejos, A.,Persson, M.,Arvela, R.K.,Wallberg, H.,Vrang, L.,Rosenquist, A.,Samuelsson, B.,Unge, J.,Larhed, M. (deposition date: 2011-10-19, release date: 2012-11-07, Last modification date: 2024-05-01) |
Primary citation | Wu, X.,Ohrngren, P.,Joshi, A.A.,Trejos, A.,Persson, M.,Arvela, R.K.,Wallberg, H.,Vrang, L.,Rosenquist, A.,Samuelsson, B.B.,Unge, J.,Larhed, M. Synthesis, X-Ray Analysis, and Biological Evaluation of a New Class of Stereopure Lactam-Based HIV-1 Protease Inhibitors. J.Med.Chem., 55:2724-, 2012 Cited by PubMed: 22376008DOI: 10.1021/JM201620T PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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