4A4O
CRYSTAL STRUCTURE OF POLO-LIKE KINASE 1 IN COMPLEX WITH A 2-(2-AMINO- PYRIMIDIN-4-YL)-1,5,6,7-TETRAHYDRO-PYRROLOPYRIDIN-4-ONE INHIBITOR
Summary for 4A4O
Entry DOI | 10.2210/pdb4a4o/pdb |
Related | 1Q4K 1Q4O 1UMW 2V5Q 2YAC 4A4L |
Descriptor | SERINE/THREONINE-PROTEIN KINASE PLK1, ZINC ION, L(+)-TARTARIC ACID, ... (5 entities in total) |
Functional Keywords | transferase |
Biological source | HOMO SAPIENS (HUMAN) |
Total number of polymer chains | 1 |
Total formula weight | 36363.53 |
Authors | Bertrand, J.A.,Bossi, R.T. (deposition date: 2011-10-18, release date: 2012-01-11, Last modification date: 2024-05-01) |
Primary citation | Caruso, M.,Valsasina, B.,Ballinari, D.,Bertrand, J.A.,Brasca, M.G.,Caldarelli, M.,Cappella, P.,Fiorentini, F.,Gianellini, L.M.,Scolaro, A.,Beria, I. 5-(2-Amino-Pyrimidin-4-Yl)-1H-Pyrrole and 2-(2-Amino-Pyrimidin-4-Yl)-1,5,6,7-Tetrahydro-Pyrrolo[3,2-C]Pyridin-4-One Derivatives as New Classes of Selective and Orally Available Polo-Like Kinase 1 Inhibitors. Bioorg.Med.Chem.Lett., 22:96-, 2012 Cited by PubMed: 22154349DOI: 10.1016/J.BMCL.2011.11.065 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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