4A4O
CRYSTAL STRUCTURE OF POLO-LIKE KINASE 1 IN COMPLEX WITH A 2-(2-AMINO- PYRIMIDIN-4-YL)-1,5,6,7-TETRAHYDRO-PYRROLOPYRIDIN-4-ONE INHIBITOR
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | SERINE/THREONINE-PROTEIN KINASE PLK1 | polymer | 311 | 35646.5 | 1 | UniProt (P53350) Pfam (PF00069) | HOMO SAPIENS (HUMAN) | PLK1_HUMAN, POLO-LIKE KINASE 1, PLK-1, SERINE/THREONINE-PROTEIN KINASE 13, STPK13 |
| 2 | B (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 3 | C (A) | L(+)-TARTARIC ACID | non-polymer | 150.1 | 1 | Chemie (TLA) | |||
| 4 | D (A) | 1-METHYL-2-(2-{[5-(4-METHYLPIPERAZIN-1-YL)-2-(TRIFLUOROMETHOXY)PHENYL]AMINO}PYRIMIDIN-4-YL)-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE | non-polymer | 501.5 | 1 | Chemie (664) | |||
| 5 | E (A) | water | water | 18.0 | 8 | Chemie (HOH) |
Sequence modifications
A: 36 - 345 (UniProt: P53350)
| PDB | External Database | Details |
|---|---|---|
| Gly 35 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 35646.5 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 717.0 | |
| All* | Total formula weight | 36363.5 |
