4A4O

CRYSTAL STRUCTURE OF POLO-LIKE KINASE 1 IN COMPLEX WITH A 2-(2-AMINO- PYRIMIDIN-4-YL)-1,5,6,7-TETRAHYDRO-PYRROLOPYRIDIN-4-ONE INHIBITOR

Summary for 4A4O

Entry DOI	10.2210/pdb4a4o/pdb
Related	1Q4K 1Q4O 1UMW 2V5Q 2YAC 4A4L
Descriptor	SERINE/THREONINE-PROTEIN KINASE PLK1, ZINC ION, L(+)-TARTARIC ACID, ... (5 entities in total)
Functional Keywords	transferase
Biological source	HOMO SAPIENS (HUMAN)
Total number of polymer chains	1
Total formula weight	36363.53
Authors	Bertrand, J.A.,Bossi, R.T. (deposition date: 2011-10-18, release date: 2012-01-11, Last modification date: 2024-05-01)
Primary citation	Caruso, M.,Valsasina, B.,Ballinari, D.,Bertrand, J.A.,Brasca, M.G.,Caldarelli, M.,Cappella, P.,Fiorentini, F.,Gianellini, L.M.,Scolaro, A.,Beria, I. 5-(2-Amino-Pyrimidin-4-Yl)-1H-Pyrrole and 2-(2-Amino-Pyrimidin-4-Yl)-1,5,6,7-Tetrahydro-Pyrrolo[3,2-C]Pyridin-4-One Derivatives as New Classes of Selective and Orally Available Polo-Like Kinase 1 Inhibitors. Bioorg.Med.Chem.Lett., 22:96-, 2012 Cited by PubMed: 22154349 DOI: 10.1016/J.BMCL.2011.11.065 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation