4A26

The crystal structure of Leishmania major N5,N10- methylenetetrahydrofolate dehydrogenase/cyclohydrolase

Summary for 4A26

• Entry DOI: 10.2210/pdb4a26/pdb
• Descriptor: PUTATIVE C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC, CHLORIDE ION (3 entities in total)
• Functional Keywords: oxidoreductase, hydrolase, leishmaniasis
• Biological source: LEISHMANIA MAJOR
• Total number of polymer chains: 2
• Total formula weight: 64023.77

Authors

Eadsforth, T.C.,Cameron, S.,Hunter, W.N. (deposition date: 2011-09-22, release date: 2011-10-26, Last modification date: 2023-12-20)

• Primary citation: Eadsforth, T.C.,Cameron, S.,Hunter, W.N.; The Crystal Structure of Leishmania Major N(5),N(10)-Methylenetetrahydrofolate Dehydrogenase/Cyclohydrolase and Assessment of a Potential Drug Target.; Mol.Biochem.Parasitol., 181:178-, 2012; PubMed: 22108435; DOI: 10.1016/J.MOLBIOPARA.2011.11.004

Experimental method

X-RAY DIFFRACTION (2.7 Å)