4A22

Structure of Mycobacterium tuberculosis fructose 1,6-bisphosphate aldolase bound to N-(4-hydroxybutyl)- glycolohydroxamic acid bis- phosphate

Summary for 4A22

• Entry DOI: 10.2210/pdb4a22/pdb
• Related: 4A21
• Descriptor: FRUCTOSE-BISPHOSPHATE ALDOLASE, 4-{hydroxy[(phosphonooxy)acetyl]amino}butyl dihydrogen phosphate, SODIUM ION, ... (6 entities in total)
• Functional Keywords: lyase, lyase-inhibitor complex
• Biological source: MYCOBACTERIUM TUBERCULOSIS
• Total number of polymer chains: 4
• Total formula weight: 148025.04

Authors

Coincon, M.,De la Paz Santangelo, M.,Gest, P.M.,Guerin, M.E.,Pham, H.,Ryan, G.,Puckett, S.E.,Spencer, J.S.,Gonzalez-Juarrero, M.,Daher, R.,Lenaerts, A.J.,Schnappinger, D.,Therisod, M.,Ehrt, S.,Jackson, M.,Sygusch, J. (deposition date: 2011-09-21, release date: 2011-10-12, Last modification date: 2018-11-21)

• Primary citation: de la Paz Santangelo, M.,Gest, P.M.,Guerin, M.E.,Coincon, M.,Pham, H.,Ryan, G.,Puckett, S.E.,Spencer, J.S.,Gonzalez-Juarrero, M.,Daher, R.,Lenaerts, A.J.,Schnappinger, D.,Therisod, M.,Ehrt, S.,Sygusch, J.,Jackson, M.; Glycolytic and non-glycolytic functions of Mycobacterium tuberculosis fructose-1,6-bisphosphate aldolase, an essential enzyme produced by replicating and non-replicating bacilli.; J. Biol. Chem., 286:40219-40231, 2011; PubMed: 21949126; DOI: 10.1074/jbc.M111.259440

Experimental method

X-RAY DIFFRACTION (1.9 Å)