4ZY5
Crystal Structure of p21-activated kinase 1 in complex with an inhibitor compound 17
Summary for 4ZY5
Entry DOI | 10.2210/pdb4zy5/pdb |
Related | 4ZY4 4ZY6 5BMS |
Descriptor | Serine/threonine-protein kinase PAK 1, N~2~-[(trans-4-aminocyclohexyl)methyl]-N~4~-(3-cyclopropyl-1H-pyrazol-5-yl)pyrimidine-2,4-diamine, SULFATE ION, ... (5 entities in total) |
Functional Keywords | kinase, inhibitor, complex, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm: Q13153 |
Total number of polymer chains | 2 |
Total formula weight | 68072.21 |
Authors | |
Primary citation | Crawford, J.J.,Lee, W.,Aliagas, I.,Mathieu, S.,Hoeflich, K.P.,Zhou, W.,Wang, W.,Rouge, L.,Murray, L.,La, H.,Liu, N.,Fan, P.W.,Cheong, J.,Heise, C.E.,Ramaswamy, S.,Mintzer, R.,Liu, Y.,Chao, Q.,Rudolph, J. Structure-Guided Design of Group I Selective p21-Activated Kinase Inhibitors. J.Med.Chem., 58:5121-5136, 2015 Cited by PubMed: 26030457DOI: 10.1021/acs.jmedchem.5b00572 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.35 Å) |
Structure validation
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