4ZQL

Crystal structure of TRIM24 with 3,4-dimethoxy-N-(6-(4-methoxyphenoxy)-1,3-dimethyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)benzenesulfonamide inhibitor

Summary for 4ZQL

• Entry DOI: 10.2210/pdb4zql/pdb
• Descriptor: Transcription intermediary factor 1-alpha, ZINC ION, SULFATE ION, ... (7 entities in total)
• Functional Keywords: transcriptional coactivator, histone h3 modifications, e3 protein-ubiquitin ligase activity, structural genomics, structural genomics consortium, sgc, ligase
• Biological source: Homo sapiens (Human)
• Cellular location: Nucleus : O15164
• Total number of polymer chains: 2
• Total formula weight: 44076.80

Authors

Tallant, C.,Structural Genomics Consortium (SGC),Clark, P.G.K.,Vieira, L.C.C.,Krojer, T.,Nunez-Alonso, G.,Picaud, S.,Fedorov, O.,Dixon, D.J.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Brennan, P.E.,Knapp, S. (deposition date: 2015-05-10, release date: 2015-06-17, Last modification date: 2024-01-10)

• Primary citation: Clark, P.G.,Vieira, L.C.,Tallant, C.,Fedorov, O.,Singleton, D.C.,Rogers, C.M.,Monteiro, O.P.,Bennett, J.M.,Baronio, R.,Muller, S.,Daniels, D.L.,Mendez, J.,Knapp, S.,Brennan, P.E.,Dixon, D.J.; Crystal structure of TRIM24 with 3,4-dimethoxy-N-(6-(4-methoxyphenoxy)-1,3-dimethyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)benzenesulfonamide inhibitor; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.79 Å)