4ZOP
Co-crystal Structure of Lipid Kinase PI3K alpha with a selective phosphatidylinositol-3 kinase alpha inhibitor
Summary for 4ZOP
Entry DOI | 10.2210/pdb4zop/pdb |
Descriptor | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, Phosphatidylinositol 3-kinase regulatory subunit alpha, (2S,3R)-N~1~-(8-tert-butyl-4,5-dihydro[1,3]thiazolo[4,5-h]quinazolin-2-yl)-3-methylpyrrolidine-1,2-dicarboxamide, ... (4 entities in total) |
Functional Keywords | lipid kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 160458.61 |
Authors | Knapp, M.S.,Elling, R.A. (deposition date: 2015-05-06, release date: 2016-05-18, Last modification date: 2023-09-27) |
Primary citation | Fairhurst, R.A.,Gerspacher, M.,Imbach-Weese, P.,Mah, R.,Caravatti, G.,Fuert, P.,Fritsch, C.,Schnell, C.,Blanz, J.,Blasco, F.,Desrayaud, S.,Guthy, D.A.,Knapp, M.S.,Arz, D.,Wirth, J.,Roehn-Carnemolla, E.,Luu, V.H. Co-crystal Structure of the Lipid Kinase PI3K alpha with a selective phosphatidylinositol-3 kinase alpha inhibitorCo-crystal Structure of the Lipid Kinase PI3K alpha with a selective phosphatidylinositol-3 kinase alpha inhibitor To Be Published, |
Experimental method | X-RAY DIFFRACTION (2.62 Å) |
Structure validation
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