4ZLS
HIV-1 wild Type protease with GRL-096-13A (a Boc-derivative P2-Ligand, 3,-5-dimethylbiphenyl P1-Ligand)
Summary for 4ZLS
Entry DOI | 10.2210/pdb4zls/pdb |
Related | 2IEN 3OK9 3QAA 4U8W |
Descriptor | Protease, SODIUM ION, CHLORIDE ION, ... (6 entities in total) |
Functional Keywords | multidrug-resistant strains, hydrolase inhibitor complex, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Human immunodeficiency virus type 1 BH10 (HIV-1) |
Cellular location | Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03366 |
Total number of polymer chains | 2 |
Total formula weight | 22312.55 |
Authors | Wang, Y.-F.,Agniswamy, J.,Weber, I.T. (deposition date: 2015-05-01, release date: 2015-07-15, Last modification date: 2023-09-27) |
Primary citation | Ghosh, A.K.,Yu, X.,Osswald, H.L.,Agniswamy, J.,Wang, Y.F.,Amano, M.,Weber, I.T.,Mitsuya, H. Structure-Based Design of Potent HIV-1 Protease Inhibitors with Modified P1-Biphenyl Ligands: Synthesis, Biological Evaluation, and Enzyme-Inhibitor X-ray Structural Studies. J.Med.Chem., 58:5334-5343, 2015 Cited by PubMed: 26107245DOI: 10.1021/acs.jmedchem.5b00676 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.53 Å) |
Structure validation
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