4Z76
Weak TCR binding to an unstable insulin epitope drives type 1 diabetes
Summary for 4Z76
Entry DOI | 10.2210/pdb4z76/pdb |
Descriptor | H-2 class I histocompatibility antigen, K-D alpha chain, Beta-2-microglobulin, Insulin, ... (7 entities in total) |
Functional Keywords | immunoglobulin, h-2kd, type 1 diabetes, immune system |
Biological source | Mus musculus (House Mouse) More |
Cellular location | Membrane; Single-pass type I membrane protein: P01902 Secreted : P61769 P01308 |
Total number of polymer chains | 6 |
Total formula weight | 92658.92 |
Authors | Rizkallah, P.J.,Cole, D.K. (deposition date: 2015-04-06, release date: 2015-06-24, Last modification date: 2015-08-12) |
Primary citation | Motozono, C.,Pearson, J.A.,De Leenheer, E.,Rizkallah, P.J.,Beck, K.,Trimby, A.,Sewell, A.K.,Wong, F.S.,Cole, D.K. Distortion of the Major Histocompatibility Complex Class I Binding Groove to Accommodate an Insulin-derived 10-Mer Peptide. J.Biol.Chem., 290:18924-18933, 2015 Cited by PubMed: 26085090DOI: 10.1074/jbc.M114.622522 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.88 Å) |
Structure validation
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