Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4Z76

Weak TCR binding to an unstable insulin epitope drives type 1 diabetes

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0000139	cellular_component	Golgi membrane
B	0001913	biological_process	T cell mediated cytotoxicity
B	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
B	0002237	biological_process	response to molecule of bacterial origin
B	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
B	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
B	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
B	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
B	0002726	biological_process	positive regulation of T cell cytokine production
B	0005198	molecular_function	structural molecule activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005765	cellular_component	lysosomal membrane
B	0005783	cellular_component	endoplasmic reticulum
B	0005788	cellular_component	endoplasmic reticulum lumen
B	0005794	cellular_component	Golgi apparatus
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0005925	cellular_component	focal adhesion
B	0006826	biological_process	iron ion transport
B	0006879	biological_process	intracellular iron ion homeostasis
B	0006955	biological_process	immune response
B	0007608	biological_process	sensory perception of smell
B	0007611	biological_process	learning or memory
B	0009897	cellular_component	external side of plasma membrane
B	0009986	cellular_component	cell surface
B	0010977	biological_process	negative regulation of neuron projection development
B	0012507	cellular_component	ER to Golgi transport vesicle membrane
B	0016020	cellular_component	membrane
B	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
B	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
B	0023026	molecular_function	MHC class II protein complex binding
B	0030670	cellular_component	phagocytic vesicle membrane
B	0031901	cellular_component	early endosome membrane
B	0031902	cellular_component	late endosome membrane
B	0031905	cellular_component	early endosome lumen
B	0032092	biological_process	positive regulation of protein binding
B	0033077	biological_process	T cell differentiation in thymus
B	0034756	biological_process	regulation of iron ion transport
B	0035580	cellular_component	specific granule lumen
B	0042026	biological_process	protein refolding
B	0042605	molecular_function	peptide antigen binding
B	0042612	cellular_component	MHC class I protein complex
B	0042613	cellular_component	MHC class II protein complex
B	0042802	molecular_function	identical protein binding
B	0042803	molecular_function	protein homodimerization activity
B	0042824	cellular_component	MHC class I peptide loading complex
B	0045646	biological_process	regulation of erythrocyte differentiation
B	0048260	biological_process	positive regulation of receptor-mediated endocytosis
B	0050680	biological_process	negative regulation of epithelial cell proliferation
B	0050768	biological_process	negative regulation of neurogenesis
B	0050778	biological_process	positive regulation of immune response
B	0050870	biological_process	positive regulation of T cell activation
B	0051289	biological_process	protein homotetramerization
B	0055038	cellular_component	recycling endosome membrane
B	0060586	biological_process	multicellular organismal-level iron ion homeostasis
B	0070062	cellular_component	extracellular exosome
B	0071281	biological_process	cellular response to iron ion
B	0071283	biological_process	cellular response to iron(III) ion
B	0071316	biological_process	cellular response to nicotine
B	1900121	biological_process	negative regulation of receptor binding
B	1900122	biological_process	positive regulation of receptor binding
B	1904434	biological_process	positive regulation of ferrous iron binding
B	1904437	biological_process	positive regulation of transferrin receptor binding
B	1904724	cellular_component	tertiary granule lumen
B	1990000	biological_process	amyloid fibril formation
B	1990712	cellular_component	HFE-transferrin receptor complex
B	2000774	biological_process	positive regulation of cellular senescence
B	2000978	biological_process	negative regulation of forebrain neuron differentiation
E	0000139	cellular_component	Golgi membrane
E	0001913	biological_process	T cell mediated cytotoxicity
E	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
E	0002237	biological_process	response to molecule of bacterial origin
E	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
E	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
E	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
E	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
E	0002726	biological_process	positive regulation of T cell cytokine production
E	0005198	molecular_function	structural molecule activity
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005615	cellular_component	extracellular space
E	0005765	cellular_component	lysosomal membrane
E	0005783	cellular_component	endoplasmic reticulum
E	0005788	cellular_component	endoplasmic reticulum lumen
E	0005794	cellular_component	Golgi apparatus
E	0005829	cellular_component	cytosol
E	0005886	cellular_component	plasma membrane
E	0005925	cellular_component	focal adhesion
E	0006826	biological_process	iron ion transport
E	0006879	biological_process	intracellular iron ion homeostasis
E	0006955	biological_process	immune response
E	0007608	biological_process	sensory perception of smell
E	0007611	biological_process	learning or memory
E	0009897	cellular_component	external side of plasma membrane
E	0009986	cellular_component	cell surface
E	0010977	biological_process	negative regulation of neuron projection development
E	0012507	cellular_component	ER to Golgi transport vesicle membrane
E	0016020	cellular_component	membrane
E	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
E	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
E	0023026	molecular_function	MHC class II protein complex binding
E	0030670	cellular_component	phagocytic vesicle membrane
E	0031901	cellular_component	early endosome membrane
E	0031902	cellular_component	late endosome membrane
E	0031905	cellular_component	early endosome lumen
E	0032092	biological_process	positive regulation of protein binding
E	0033077	biological_process	T cell differentiation in thymus
E	0034756	biological_process	regulation of iron ion transport
E	0035580	cellular_component	specific granule lumen
E	0042026	biological_process	protein refolding
E	0042605	molecular_function	peptide antigen binding
E	0042612	cellular_component	MHC class I protein complex
E	0042613	cellular_component	MHC class II protein complex
E	0042802	molecular_function	identical protein binding
E	0042803	molecular_function	protein homodimerization activity
E	0042824	cellular_component	MHC class I peptide loading complex
E	0045646	biological_process	regulation of erythrocyte differentiation
E	0048260	biological_process	positive regulation of receptor-mediated endocytosis
E	0050680	biological_process	negative regulation of epithelial cell proliferation
E	0050768	biological_process	negative regulation of neurogenesis
E	0050778	biological_process	positive regulation of immune response
E	0050870	biological_process	positive regulation of T cell activation
E	0051289	biological_process	protein homotetramerization
E	0055038	cellular_component	recycling endosome membrane
E	0060586	biological_process	multicellular organismal-level iron ion homeostasis
E	0070062	cellular_component	extracellular exosome
E	0071281	biological_process	cellular response to iron ion
E	0071283	biological_process	cellular response to iron(III) ion
E	0071316	biological_process	cellular response to nicotine
E	1900121	biological_process	negative regulation of receptor binding
E	1900122	biological_process	positive regulation of receptor binding
E	1904434	biological_process	positive regulation of ferrous iron binding
E	1904437	biological_process	positive regulation of transferrin receptor binding
E	1904724	cellular_component	tertiary granule lumen
E	1990000	biological_process	amyloid fibril formation
E	1990712	cellular_component	HFE-transferrin receptor complex
E	2000774	biological_process	positive regulation of cellular senescence
E	2000978	biological_process	negative regulation of forebrain neuron differentiation

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue EDO A 301

Chain	Residue
A	GLU232
A	HOH408
A	HOH413
B	GLN8
B	SER28
B	HOH422

site_id	AC2
Number of Residues	7
Details	binding site for residue EDO A 302

Chain	Residue
A	ARG144
A	HOH436
A	HOH445
E	LYS91
A	ASN127
A	THR132
A	TRP133

site_id	AC3
Number of Residues	4
Details	binding site for residue GOL A 303

Chain	Residue
A	ARG145
A	GLN149
D	GLN218
D	HOH403

site_id	AC4
Number of Residues	8
Details	binding site for residue GOL A 304

Chain	Residue
A	TYR84
A	TYR85
A	ASP137
A	THR138
A	ALA139
D	ASP212
D	THR214
D	HOH533

site_id	AC5
Number of Residues	6
Details	binding site for residue SO4 A 305

Chain	Residue
A	SER13
A	ARG14
A	GLY18
A	GLU19
A	PRO20
A	ARG75

site_id	AC6
Number of Residues	8
Details	binding site for residue EDO B 301

Chain	Residue
A	TRP204
A	ARG234
A	GLN242
B	TYR10
B	SER11
B	HIS13
B	PRO14
B	HOH444

site_id	AC7
Number of Residues	7
Details	binding site for residue EDO B 302

Chain	Residue
A	VAL231
A	ARG234
B	GLN8
B	VAL9
B	MET99
B	HOH439
B	HOH451

site_id	AC8
Number of Residues	5
Details	binding site for residue EDO B 303

Chain	Residue
B	LYS6
B	ILE7
B	LYS91
B	HOH461
D	HOH417

site_id	AC9
Number of Residues	6
Details	binding site for residue SO4 B 304

Chain	Residue
A	ARG6
A	PHE8
B	SER57
B	LYS58
B	HOH409
B	HOH446

site_id	AD1
Number of Residues	7
Details	binding site for residue SO4 B 305

Chain	Residue
B	ASP34
B	ILE35
B	GLU36
B	ASN83
B	HIS84
B	VAL85
B	HOH412

site_id	AD2
Number of Residues	5
Details	binding site for residue SO4 B 306

Chain	Residue
A	ARG21
A	HOH486
B	SER33
B	ASP34
B	LEU54

site_id	AD3
Number of Residues	6
Details	binding site for residue SO4 D 301

Chain	Residue
B	LYS75
D	PRO47
D	ARG48
D	ALA49
D	PRO50
D	GLU53

site_id	AD4
Number of Residues	5
Details	binding site for residue SO4 D 302

Chain	Residue
B	MET0
B	ILE1
B	GLN2
D	ARG111
D	TYR113

site_id	AD5
Number of Residues	10
Details	binding site for residue SO4 D 303

Chain	Residue
A	LYS264
A	HOH411
B	SER88
B	GLN89
D	ALA135
D	ALA136
D	ASP137
D	THR138
D	LEU141
D	HOH522

site_id	AD6
Number of Residues	6
Details	binding site for residue SO4 D 304

Chain	Residue
B	GLU74
B	LYS75
D	LEU219
D	LYS253
D	ASN256
D	TYR257

site_id	AD7
Number of Residues	3
Details	binding site for residue SO4 D 305

Chain	Residue
D	GLU166
D	TRP167
D	ARG170

site_id	AD8
Number of Residues	6
Details	binding site for residue SO4 D 306

Chain	Residue
D	SER13
D	ARG14
D	GLY18
D	GLU19
D	PRO20
D	HOH439

site_id	AD9
Number of Residues	3
Details	binding site for residue EDO E 101

Chain	Residue
E	LYS6
E	ILE7
E	LYS91

site_id	AE1
Number of Residues	6
Details	binding site for residue GOL E 102

Chain	Residue
A	ASP122
D	GLY1
D	SER105
E	VAL85
E	THR86
E	HOH270

site_id	AE2
Number of Residues	9
Details	binding site for residue SO4 E 103

Chain	Residue
E	LEU40
E	LYS41
E	ASN42
E	GLY43
E	GLU77
E	TYR78
E	ALA79
E	HOH210
E	HOH230

site_id	AE3
Number of Residues	11
Details	binding site for residue SO4 E 104

Chain	Residue
D	TRP204
D	LEU206
D	ARG234
D	GLN242
E	TYR10
E	SER11
E	ARG12
E	HIS13
E	PRO14
E	HOH242
E	HOH243

site_id	AE4
Number of Residues	3
Details	binding site for residue SO4 E 105

Chain	Residue
E	SER57
E	LYS58
E	HOH225

site_id	AE5
Number of Residues	5
Details	binding site for residue SO4 E 106

Chain	Residue
A	ARG111
A	TYR113
E	MET0
E	ILE1
E	GLN2

site_id	AE6
Number of Residues	8
Details	binding site for residue SO4 E 107

Chain	Residue
B	ARG45
B	GLU47
E	SER20
E	ASN21
E	PHE22
E	GLU69
E	HOH207
E	HOH211

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACRVNH

Chain	Residue	Details
B	TYR78-HIS84
A	TYR257-HIS263

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	MOD_RES: Pyrrolidone carboxylic acid; in form pI 5.3 => ECO:0000269\|PubMed:7554280

Chain	Residue	Details
B	GLN2
E	GLN2

site_id	SWS_FT_FI2
Number of Residues	2
Details	CARBOHYD: N-linked (Glc) (glycation) isoleucine; in hemodialysis-associated amyloidosis => ECO:0000269\|PubMed:7918443

Chain	Residue	Details
B	ILE1
E	ILE1

site_id	SWS_FT_FI3
Number of Residues	12
Details	CARBOHYD: N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269\|PubMed:7918443

Chain	Residue	Details
B	LYS19
E	LYS58
E	LYS91
E	LYS94
B	LYS41
B	LYS48
B	LYS58
B	LYS91
B	LYS94
E	LYS19
E	LYS41
E	LYS48

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)