4Z5R

Rontalizumab Fab bound to Interferon-a2

Summary for 4Z5R

• Entry DOI: 10.2210/pdb4z5r/pdb
• Descriptor: Interferon alpha-2, anti-IFN-a antibody rontalizumab light chain, anti-IFN-a antibody rontalizumab heavy chain modules VH and CH1 (Fab), ... (4 entities in total)
• Functional Keywords: antibody, interferon, cytokine-immune system complex, cytokine/immune system
• Biological source: Homo sapiens (Human); More
• Cellular location: Secreted: P01563
• Total number of polymer chains: 24
• Total formula weight: 540246.16

Authors

Eigenbrot, C.,Maurer, B.,Bosanac, I. (deposition date: 2015-04-02, release date: 2015-07-08, Last modification date: 2023-09-27)

• Primary citation: Maurer, B.,Bosanac, I.,Shia, S.,Kwong, M.,Corpuz, R.,Vandlen, R.,Schmidt, K.,Eigenbrot, C.; Structural basis of the broadly neutralizing anti-interferon-alpha antibody rontalizumab.; Protein Sci., 24:1440-1450, 2015; PubMed: 26099203; DOI: 10.1002/pro.2729

Experimental method

X-RAY DIFFRACTION (3 Å)