Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4Z5R

Rontalizumab Fab bound to Interferon-a2

Functional Information from GO Data

Chain	GOid	namespace	contents
D	0002250	biological_process	adaptive immune response
D	0002286	biological_process	T cell activation involved in immune response
D	0002312	biological_process	B cell activation involved in immune response
D	0002323	biological_process	natural killer cell activation involved in immune response
D	0005125	molecular_function	cytokine activity
D	0005126	molecular_function	cytokine receptor binding
D	0005132	molecular_function	type I interferon receptor binding
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0006915	biological_process	apoptotic process
D	0006952	biological_process	defense response
D	0006954	biological_process	inflammatory response
D	0006959	biological_process	humoral immune response
D	0007166	biological_process	cell surface receptor signaling pathway
D	0007267	biological_process	cell-cell signaling
D	0010629	biological_process	negative regulation of gene expression
D	0031012	cellular_component	extracellular matrix
D	0032696	biological_process	negative regulation of interleukin-13 production
D	0032714	biological_process	negative regulation of interleukin-5 production
D	0043330	biological_process	response to exogenous dsRNA
D	0045581	biological_process	negative regulation of T cell differentiation
D	0045892	biological_process	negative regulation of DNA-templated transcription
D	0046597	biological_process	host-mediated suppression of symbiont invasion
D	0051607	biological_process	defense response to virus
D	0060337	biological_process	type I interferon-mediated signaling pathway
D	0097696	biological_process	cell surface receptor signaling pathway via STAT
D	0098586	biological_process	cellular response to virus
D	2000552	biological_process	negative regulation of T-helper 2 cell cytokine production
E	0002250	biological_process	adaptive immune response
E	0002286	biological_process	T cell activation involved in immune response
E	0002312	biological_process	B cell activation involved in immune response
E	0002323	biological_process	natural killer cell activation involved in immune response
E	0005125	molecular_function	cytokine activity
E	0005126	molecular_function	cytokine receptor binding
E	0005132	molecular_function	type I interferon receptor binding
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005615	cellular_component	extracellular space
E	0006915	biological_process	apoptotic process
E	0006952	biological_process	defense response
E	0006954	biological_process	inflammatory response
E	0006959	biological_process	humoral immune response
E	0007166	biological_process	cell surface receptor signaling pathway
E	0007267	biological_process	cell-cell signaling
E	0010629	biological_process	negative regulation of gene expression
E	0031012	cellular_component	extracellular matrix
E	0032696	biological_process	negative regulation of interleukin-13 production
E	0032714	biological_process	negative regulation of interleukin-5 production
E	0043330	biological_process	response to exogenous dsRNA
E	0045581	biological_process	negative regulation of T cell differentiation
E	0045892	biological_process	negative regulation of DNA-templated transcription
E	0046597	biological_process	host-mediated suppression of symbiont invasion
E	0051607	biological_process	defense response to virus
E	0060337	biological_process	type I interferon-mediated signaling pathway
E	0097696	biological_process	cell surface receptor signaling pathway via STAT
E	0098586	biological_process	cellular response to virus
E	2000552	biological_process	negative regulation of T-helper 2 cell cytokine production
F	0002250	biological_process	adaptive immune response
F	0002286	biological_process	T cell activation involved in immune response
F	0002312	biological_process	B cell activation involved in immune response
F	0002323	biological_process	natural killer cell activation involved in immune response
F	0005125	molecular_function	cytokine activity
F	0005126	molecular_function	cytokine receptor binding
F	0005132	molecular_function	type I interferon receptor binding
F	0005515	molecular_function	protein binding
F	0005576	cellular_component	extracellular region
F	0005615	cellular_component	extracellular space
F	0006915	biological_process	apoptotic process
F	0006952	biological_process	defense response
F	0006954	biological_process	inflammatory response
F	0006959	biological_process	humoral immune response
F	0007166	biological_process	cell surface receptor signaling pathway
F	0007267	biological_process	cell-cell signaling
F	0010629	biological_process	negative regulation of gene expression
F	0031012	cellular_component	extracellular matrix
F	0032696	biological_process	negative regulation of interleukin-13 production
F	0032714	biological_process	negative regulation of interleukin-5 production
F	0043330	biological_process	response to exogenous dsRNA
F	0045581	biological_process	negative regulation of T cell differentiation
F	0045892	biological_process	negative regulation of DNA-templated transcription
F	0046597	biological_process	host-mediated suppression of symbiont invasion
F	0051607	biological_process	defense response to virus
F	0060337	biological_process	type I interferon-mediated signaling pathway
F	0097696	biological_process	cell surface receptor signaling pathway via STAT
F	0098586	biological_process	cellular response to virus
F	2000552	biological_process	negative regulation of T-helper 2 cell cytokine production
G	0002250	biological_process	adaptive immune response
G	0002286	biological_process	T cell activation involved in immune response
G	0002312	biological_process	B cell activation involved in immune response
G	0002323	biological_process	natural killer cell activation involved in immune response
G	0005125	molecular_function	cytokine activity
G	0005126	molecular_function	cytokine receptor binding
G	0005132	molecular_function	type I interferon receptor binding
G	0005515	molecular_function	protein binding
G	0005576	cellular_component	extracellular region
G	0005615	cellular_component	extracellular space
G	0006915	biological_process	apoptotic process
G	0006952	biological_process	defense response
G	0006954	biological_process	inflammatory response
G	0006959	biological_process	humoral immune response
G	0007166	biological_process	cell surface receptor signaling pathway
G	0007267	biological_process	cell-cell signaling
G	0010629	biological_process	negative regulation of gene expression
G	0031012	cellular_component	extracellular matrix
G	0032696	biological_process	negative regulation of interleukin-13 production
G	0032714	biological_process	negative regulation of interleukin-5 production
G	0043330	biological_process	response to exogenous dsRNA
G	0045581	biological_process	negative regulation of T cell differentiation
G	0045892	biological_process	negative regulation of DNA-templated transcription
G	0046597	biological_process	host-mediated suppression of symbiont invasion
G	0051607	biological_process	defense response to virus
G	0060337	biological_process	type I interferon-mediated signaling pathway
G	0097696	biological_process	cell surface receptor signaling pathway via STAT
G	0098586	biological_process	cellular response to virus
G	2000552	biological_process	negative regulation of T-helper 2 cell cytokine production
H	0002250	biological_process	adaptive immune response
H	0002286	biological_process	T cell activation involved in immune response
H	0002312	biological_process	B cell activation involved in immune response
H	0002323	biological_process	natural killer cell activation involved in immune response
H	0005125	molecular_function	cytokine activity
H	0005126	molecular_function	cytokine receptor binding
H	0005132	molecular_function	type I interferon receptor binding
H	0005515	molecular_function	protein binding
H	0005576	cellular_component	extracellular region
H	0005615	cellular_component	extracellular space
H	0006915	biological_process	apoptotic process
H	0006952	biological_process	defense response
H	0006954	biological_process	inflammatory response
H	0006959	biological_process	humoral immune response
H	0007166	biological_process	cell surface receptor signaling pathway
H	0007267	biological_process	cell-cell signaling
H	0010629	biological_process	negative regulation of gene expression
H	0031012	cellular_component	extracellular matrix
H	0032696	biological_process	negative regulation of interleukin-13 production
H	0032714	biological_process	negative regulation of interleukin-5 production
H	0043330	biological_process	response to exogenous dsRNA
H	0045581	biological_process	negative regulation of T cell differentiation
H	0045892	biological_process	negative regulation of DNA-templated transcription
H	0046597	biological_process	host-mediated suppression of symbiont invasion
H	0051607	biological_process	defense response to virus
H	0060337	biological_process	type I interferon-mediated signaling pathway
H	0097696	biological_process	cell surface receptor signaling pathway via STAT
H	0098586	biological_process	cellular response to virus
H	2000552	biological_process	negative regulation of T-helper 2 cell cytokine production
I	0002250	biological_process	adaptive immune response
I	0002286	biological_process	T cell activation involved in immune response
I	0002312	biological_process	B cell activation involved in immune response
I	0002323	biological_process	natural killer cell activation involved in immune response
I	0005125	molecular_function	cytokine activity
I	0005126	molecular_function	cytokine receptor binding
I	0005132	molecular_function	type I interferon receptor binding
I	0005515	molecular_function	protein binding
I	0005576	cellular_component	extracellular region
I	0005615	cellular_component	extracellular space
I	0006915	biological_process	apoptotic process
I	0006952	biological_process	defense response
I	0006954	biological_process	inflammatory response
I	0006959	biological_process	humoral immune response
I	0007166	biological_process	cell surface receptor signaling pathway
I	0007267	biological_process	cell-cell signaling
I	0010629	biological_process	negative regulation of gene expression
I	0031012	cellular_component	extracellular matrix
I	0032696	biological_process	negative regulation of interleukin-13 production
I	0032714	biological_process	negative regulation of interleukin-5 production
I	0043330	biological_process	response to exogenous dsRNA
I	0045581	biological_process	negative regulation of T cell differentiation
I	0045892	biological_process	negative regulation of DNA-templated transcription
I	0046597	biological_process	host-mediated suppression of symbiont invasion
I	0051607	biological_process	defense response to virus
I	0060337	biological_process	type I interferon-mediated signaling pathway
I	0097696	biological_process	cell surface receptor signaling pathway via STAT
I	0098586	biological_process	cellular response to virus
I	2000552	biological_process	negative regulation of T-helper 2 cell cytokine production
N	0002250	biological_process	adaptive immune response
N	0002286	biological_process	T cell activation involved in immune response
N	0002312	biological_process	B cell activation involved in immune response
N	0002323	biological_process	natural killer cell activation involved in immune response
N	0005125	molecular_function	cytokine activity
N	0005126	molecular_function	cytokine receptor binding
N	0005132	molecular_function	type I interferon receptor binding
N	0005515	molecular_function	protein binding
N	0005576	cellular_component	extracellular region
N	0005615	cellular_component	extracellular space
N	0006915	biological_process	apoptotic process
N	0006952	biological_process	defense response
N	0006954	biological_process	inflammatory response
N	0006959	biological_process	humoral immune response
N	0007166	biological_process	cell surface receptor signaling pathway
N	0007267	biological_process	cell-cell signaling
N	0010629	biological_process	negative regulation of gene expression
N	0031012	cellular_component	extracellular matrix
N	0032696	biological_process	negative regulation of interleukin-13 production
N	0032714	biological_process	negative regulation of interleukin-5 production
N	0043330	biological_process	response to exogenous dsRNA
N	0045581	biological_process	negative regulation of T cell differentiation
N	0045892	biological_process	negative regulation of DNA-templated transcription
N	0046597	biological_process	host-mediated suppression of symbiont invasion
N	0051607	biological_process	defense response to virus
N	0060337	biological_process	type I interferon-mediated signaling pathway
N	0097696	biological_process	cell surface receptor signaling pathway via STAT
N	0098586	biological_process	cellular response to virus
N	2000552	biological_process	negative regulation of T-helper 2 cell cytokine production
X	0002250	biological_process	adaptive immune response
X	0002286	biological_process	T cell activation involved in immune response
X	0002312	biological_process	B cell activation involved in immune response
X	0002323	biological_process	natural killer cell activation involved in immune response
X	0005125	molecular_function	cytokine activity
X	0005126	molecular_function	cytokine receptor binding
X	0005132	molecular_function	type I interferon receptor binding
X	0005515	molecular_function	protein binding
X	0005576	cellular_component	extracellular region
X	0005615	cellular_component	extracellular space
X	0006915	biological_process	apoptotic process
X	0006952	biological_process	defense response
X	0006954	biological_process	inflammatory response
X	0006959	biological_process	humoral immune response
X	0007166	biological_process	cell surface receptor signaling pathway
X	0007267	biological_process	cell-cell signaling
X	0010629	biological_process	negative regulation of gene expression
X	0031012	cellular_component	extracellular matrix
X	0032696	biological_process	negative regulation of interleukin-13 production
X	0032714	biological_process	negative regulation of interleukin-5 production
X	0043330	biological_process	response to exogenous dsRNA
X	0045581	biological_process	negative regulation of T cell differentiation
X	0045892	biological_process	negative regulation of DNA-templated transcription
X	0046597	biological_process	host-mediated suppression of symbiont invasion
X	0051607	biological_process	defense response to virus
X	0060337	biological_process	type I interferon-mediated signaling pathway
X	0097696	biological_process	cell surface receptor signaling pathway via STAT
X	0098586	biological_process	cellular response to virus
X	2000552	biological_process	negative regulation of T-helper 2 cell cytokine production

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue SO4 J 301

Chain	Residue
J	LYS39
J	LYS42
J	LYS45

site_id	AC2
Number of Residues	7
Details	binding site for residue SO4 J 302

Chain	Residue
J	ASP82
J	GLN37
J	LYS39
J	LYS45
J	ARG61
J	PHE62
J	GLU81

site_id	AC3
Number of Residues	7
Details	binding site for residue SO4 L 301

Chain	Residue
L	GLN37
L	LYS39
L	LYS45
L	ARG61
L	PHE62
L	GLU81
L	ASP82

site_id	AC4
Number of Residues	6
Details	binding site for residue SO4 F 201

Chain	Residue
F	ARG33
F	HIS34
F	VAL142
F	GLU146
W	SER97
W	ASP98

site_id	AC5
Number of Residues	7
Details	binding site for residue SO4 V 301

Chain	Residue
V	GLN37
V	LYS39
V	LYS45
V	PHE62
V	GLU81
V	ASP82
V	SO4302

site_id	AC6
Number of Residues	3
Details	binding site for residue SO4 V 302

Chain	Residue
V	LYS39
V	LYS45
V	SO4301

site_id	AC7
Number of Residues	6
Details	binding site for residue SO4 G 501

Chain	Residue
G	ARG33
G	HIS34
G	VAL142
G	GLU146
Q	SER97
Q	ASP98

site_id	AC8
Number of Residues	3
Details	binding site for residue SO4 P 301

Chain	Residue
P	GLN37
P	LYS39
P	LYS45

Functional Information from PROSITE/UniProt

site_id	PS00252
Number of Residues	19
Details	INTERFERON_A_B_D Interferon alpha, beta and delta family signature. YFqRItlYLkekkyspCAW

Chain	Residue	Details
D	TYR122-TRP140

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH

Chain	Residue	Details
J	TYR192-HIS198
K	TYR194-HIS200

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	CARBOHYD: O-linked (GalNAc...) threonine => ECO:0000269\|PubMed:2049076

Chain	Residue	Details
D	THR106
E	THR106
F	THR106
G	THR106
H	THR106
I	THR106
X	THR106
N	THR106

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)