4Z1H

Crystal structure of human Trap1 with SMTIN-P01

Summary for 4Z1H

Entry DOI	10.2210/pdb4z1h/pdb
Related	4z1f 4z1g 4z1i
Descriptor	Heat shock protein 75 kDa, mitochondrial, 8-[(6-iodo-1,3-benzodioxol-5-yl)sulfanyl]-9-[6-(triphenyl-lambda~5~-phosphanyl)hexyl]-9H-purin-6-amine (3 entities in total)
Functional Keywords	mitochondrial hsp90, chaperone
Biological source	Homo sapiens (Human)
Cellular location	Mitochondrion : Q12931
Total number of polymer chains	1
Total formula weight	58181.73
Authors	Lee, C.,Park, H.K.,Ryu, J.H.,Kang, B.H. (deposition date: 2015-03-27, release date: 2015-04-22)
Primary citation	Lee, C.,Park, H.K.,Jeong, H.,Lim, J.,Lee, A.J.,Cheon, K.Y.,Kim, C.S.,Thomas, A.P.,Bae, B.,Kim, N.D.,Kim, S.H.,Suh, P.G.,Ryu, J.H.,Kang, B.H. Development of a Mitochondria-Targeted Hsp90 Inhibitor Based on the Crystal Structures of Human TRAP1 J.Am.Chem.Soc., 137:4358-4367, 2015 Cited by PubMed: 25785725 DOI: 10.1021/ja511893n PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.9 Å)

Structure validation