4YVX
Crystal structure of AKR1C3 complexed with glimepiride
Summary for 4YVX
Entry DOI | 10.2210/pdb4yvx/pdb |
Related | 4YVP 4YVV |
Descriptor | Aldo-keto reductase family 1 member C3, 3-ethyl-4-methyl-N-[2-(4-{[(cis-4-methylcyclohexyl)carbamoyl]sulfamoyl}phenyl)ethyl]-2-oxo-2,5-dihydro-1H-pyrrole-1-car boxamide, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (4 entities in total) |
Functional Keywords | akr1c3 inhibitor, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm: P42330 |
Total number of polymer chains | 2 |
Total formula weight | 76280.50 |
Authors | |
Primary citation | Zhao, Y.,Zheng, X.,Zhang, H.,Zhai, J.,Zhang, L.,Li, C.,Zeng, K.,Chen, Y.,Li, Q.,Hu, X. In vitro inhibition of AKR1Cs by sulphonylureas and the structural basis Chem.Biol.Interact., 240:310-315, 2015 Cited by PubMed: 26362498DOI: 10.1016/j.cbi.2015.09.006 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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