4YJN
Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with inhibitor UW1639
Summary for 4YJN
Entry DOI | 10.2210/pdb4yjn/pdb |
Related | 4ONA |
Descriptor | Calmodulin-domain protein kinase 1, 5-amino-1-tert-butyl-3-[2-(cyclobutyloxy)quinolin-6-yl]-1H-pyrazole-4-carboxamide (3 entities in total) |
Functional Keywords | serine/threonine protein kinase, transferase, calcium-binding, atp-binding, bumped kinase inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Toxoplasma gondii |
Total number of polymer chains | 1 |
Total formula weight | 55606.37 |
Authors | Merritt, E.A. (deposition date: 2015-03-03, release date: 2015-11-25, Last modification date: 2023-09-27) |
Primary citation | Huang, W.,Ojo, K.K.,Zhang, Z.,Rivas, K.,Vidadala, R.S.,Scheele, S.,DeRocher, A.E.,Choi, R.,Hulverson, M.A.,Barrett, L.K.,Bruzual, I.,Siddaramaiah, L.K.,Kerchner, K.M.,Kurnick, M.D.,Freiberg, G.M.,Kempf, D.,Hol, W.G.,Merritt, E.A.,Neckermann, G.,de Hostos, E.L.,Isoherranen, N.,Maly, D.J.,Parsons, M.,Doggett, J.S.,Van Voorhis, W.C.,Fan, E. SAR Studies of 5-Aminopyrazole-4-carboxamide Analogues as Potent and Selective Inhibitors of Toxoplasma gondii CDPK1. Acs Med.Chem.Lett., 6:1184-1189, 2015 Cited by PubMed: 26693272DOI: 10.1021/acsmedchemlett.5b00319 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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