4YAQ
Crystal structure of a computationally optimized PG9 mutant
Summary for 4YAQ
Entry DOI | 10.2210/pdb4yaq/pdb |
Descriptor | PG9_N100FY Fab heavy chain, PG9_N100FY Light Chain, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total) |
Functional Keywords | antibody, hiv, immune system |
Biological source | Homo sapiens More |
Total number of polymer chains | 4 |
Total formula weight | 102242.92 |
Authors | Murrell, S.,Julien, J.P.,Wilson, I.A. (deposition date: 2015-02-17, release date: 2015-06-03, Last modification date: 2023-11-15) |
Primary citation | Willis, J.R.,Sapparapu, G.,Murrell, S.,Julien, J.P.,Singh, V.,King, H.G.,Xia, Y.,Pickens, J.A.,LaBranche, C.C.,Slaughter, J.C.,Montefiori, D.C.,Wilson, I.A.,Meiler, J.,Crowe, J.E. Redesigned HIV antibodies exhibit enhanced neutralizing potency and breadth. J.Clin.Invest., 125:2523-2531, 2015 Cited by PubMed: 25985274DOI: 10.1172/JCI80693 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
Download full validation report