4XJM

Crystal structure of 7,8-diaminopelargonic acid synthase (BioA) from Mycobacterium tuberculosis, complexed with a HTS lead compound

Summary for 4XJM

• Entry DOI: 10.2210/pdb4xjm/pdb
• Related: 4XJL 4XJO 4XJP
• Descriptor: Adenosylmethionine-8-amino-7-oxononanoate aminotransferase, 3-{1-[(5-acetylthiophen-2-yl)carbonyl]piperidin-4-yl}-N-(3-methoxyphenyl)propanamide, PYRIDOXAL-5'-PHOSPHATE, ... (4 entities in total)
• Functional Keywords: inhibitor complex transaminase plp, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
• Total number of polymer chains: 2
• Total formula weight: 98396.36

Authors

Finzel, B.C.,Dai, R. (deposition date: 2015-01-08, release date: 2016-01-20, Last modification date: 2023-09-27)

• Primary citation: Finzel, B.C.,Dai, R.; Fragment based inhibitor design of Mycobacterium tuberculosis BioA (http://hdl.handle.net/11299/171084); Thesis, University of Minnesota, 2015

Experimental method

X-RAY DIFFRACTION (1.6 Å)