4XJ0
Crystal structure of ERK2 in complex with an inhibitor 14K
Summary for 4XJ0
Entry DOI | 10.2210/pdb4xj0/pdb |
Descriptor | Mitogen-activated protein kinase 1, 1-[(1S)-1-(4-chloro-3-fluorophenyl)-2-hydroxyethyl]-4-[2-(tetrahydro-2H-pyran-4-ylamino)pyrimidin-4-yl]pyridin-2(1H)-one (3 entities in total) |
Functional Keywords | protein kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm, cytoskeleton, spindle : P28482 |
Total number of polymer chains | 2 |
Total formula weight | 82257.12 |
Authors | |
Primary citation | Ren, L.,Grina, J.,Moreno, D.,Blake, J.F.,Gaudino, J.J.,Garrey, R.,Metcalf, A.T.,Burkard, M.,Martinson, M.,Rasor, K.,Chen, H.,Dean, B.,Gould, S.E.,Pacheco, P.,Shahidi-Latham, S.,Yin, J.,West, K.,Wang, W.,Moffat, J.G.,Schwarz, J.B. Discovery of highly potent, selective, and efficacious small molecule inhibitors of ERK1/2. J.Med.Chem., 58:1976-1991, 2015 Cited by PubMed: 25603482DOI: 10.1021/jm501921k PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.58 Å) |
Structure validation
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