4XJ0
Crystal structure of ERK2 in complex with an inhibitor 14K
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Mitogen-activated protein kinase 1 | polymer | 349 | 40683.7 | 2 | UniProt (P28482) Pfam (PF00069) | Homo sapiens (Human) | MAPK 1,ERT1,Extracellular signal-regulated kinase 2,ERK-2,MAP kinase isoform p42,p42-MAPK,Mitogen-activated protein kinase 2,MAPK 2 |
| 2 | C, D (A, B) | 1-[(1S)-1-(4-chloro-3-fluorophenyl)-2-hydroxyethyl]-4-[2-(tetrahydro-2H-pyran-4-ylamino)pyrimidin-4-yl]pyridin-2(1H)-one | non-polymer | 444.9 | 2 | Chemie (41B) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 120 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 81367.4 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 889.8 | |
| All* | Total formula weight | 82257.1 |
