4XGK
Crystal structure of UDP-galactopyranose mutase from Corynebacterium diphtheriae in complex with 2-[4-(4-chlorophenyl)-7-(2-thienyl)-2-thia-5,6,8,9-tetrazabicyclo[4.3.0]nona-4,7,9-trien-3-yl]acetic
Summary for 4XGK
Entry DOI | 10.2210/pdb4xgk/pdb |
Descriptor | UDP-galactopyranose mutase, SULFATE ION, [(7S)-6-(4-chlorophenyl)-3-(thiophen-2-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-7-yl]acetic acid, ... (5 entities in total) |
Functional Keywords | udp-galactopyranose mutase, corynebacterium diphtheriae, inhibitor, galactofuranose, isomerase-isomerase inhibitor complex, isomerase/isomerase inhibitor |
Biological source | Corynebacterium diphtheriae |
Total number of polymer chains | 2 |
Total formula weight | 93345.25 |
Authors | Wangkanont, K.,Heroux, A.,Forest, K.T.,Kiessling, L.L. (deposition date: 2014-12-31, release date: 2015-08-12, Last modification date: 2023-09-27) |
Primary citation | Kincaid, V.A.,London, N.,Wangkanont, K.,Wesener, D.A.,Marcus, S.A.,Heroux, A.,Nedyalkova, L.,Talaat, A.M.,Forest, K.T.,Shoichet, B.K.,Kiessling, L.L. Virtual Screening for UDP-Galactopyranose Mutase Ligands Identifies a New Class of Antimycobacterial Agents. Acs Chem.Biol., 10:2209-2218, 2015 Cited by PubMed: 26214585DOI: 10.1021/acschembio.5b00370 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.652 Å) |
Structure validation
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