4XE4

Coagulation Factor XII protease domain crystal structure

Summary for 4XE4

• Entry DOI: 10.2210/pdb4xe4/pdb
• Related PRD ID: PRD_900017
• Descriptor: Coagulation factor XII, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ... (4 entities in total)
• Functional Keywords: factor xii, zymogens, catalytic domain, active site, blood clotting
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 28352.64

Authors

Pathak, M.,Wilmann, P.,Awford, J.,Li, C.,Fisher, P.M.,Dreveny, I.,Dekker, L.V.,Emsley, J. (deposition date: 2014-12-22, release date: 2015-02-04, Last modification date: 2024-01-10)

Primary citation

Pathak, M.,Wilmann, P.,Awford, J.,Li, C.,Hamad, B.K.,Fischer, P.M.,Dreveny, I.,Dekker, L.V.,Emsley, J.
Coagulation factor XII protease domain crystal structure.
J.Thromb.Haemost., 13:580-591, 2015

PubMed Abstract: Coagulation factor XII is a serine protease that is important for kinin generation and blood coagulation, cleaving the substrates plasma kallikrein and FXI.

PubMed: 25604127
DOI: 10.1111/jth.12849

Experimental method

X-RAY DIFFRACTION (2.4 Å)