4XE4

Coagulation Factor XII protease domain crystal structure

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Coagulation factor XII	polymer	255	27633.0	1	UniProt (P00748) Pfam (PF00089)	Homo sapiens (Human)	Hageman factor,HAF
2	B (B)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		627.6	1	In PDB BIRD (PRD_900017) GlyTouCan (G47362BJ)		triacetyl-beta-chitotriose
3	C (A)	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
4	D (A)	water	water		18.0	78	Chemie (HOH)

Sequence modifications

A: 354 - 596 (UniProt: P00748)

PDB	External Database	Details
Ser 467	Cys 486	engineered mutation
His 597	-	expression tag
His 598	-	expression tag
Thr 599	-	expression tag
Gly 600	-	expression tag
Thr 601	-	expression tag
Arg 602	-	expression tag
His 603	-	expression tag
His 604	-	expression tag
His 605	-	expression tag
His 606	-	expression tag
His 607	-	expression tag
His 608	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	27633.0
Branched	Number of molecules	1
	Total formula weight	627.6
Non-Polymers*	Number of molecules	1
	Total formula weight	92.1
All*	Total formula weight	28352.6

*Water molecules are not included.