4X8G
Crystal structure of human peptidylarginine deiminase type4 (PAD4) in complex with GSK199
Summary for 4X8G
Entry DOI | 10.2210/pdb4x8g/pdb |
Related | 4X8C |
Descriptor | Protein-arginine deiminase type-4, CALCIUM ION, [(3R)-3-aminopiperidin-1-yl][2-(1-ethyl-1H-pyrrolo[2,3-b]pyridin-2-yl)-7-methoxy-1-methyl-1H-benzimidazol-5-yl]methanone, ... (4 entities in total) |
Functional Keywords | hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm: Q9UM07 |
Total number of polymer chains | 1 |
Total formula weight | 75510.67 |
Authors | Lewis, H.D.,Bax, B.D.,Chung, C.-W.,Polyakova, O.,Thorpe, J. (deposition date: 2014-12-10, release date: 2015-01-28, Last modification date: 2024-02-28) |
Primary citation | Lewis, H.D.,Liddle, J.,Coote, J.E.,Atkinson, S.J.,Barker, M.D.,Bax, B.D.,Bicker, K.L.,Bingham, R.P.,Campbell, M.,Chen, Y.H.,Chung, C.W.,Craggs, P.D.,Davis, R.P.,Eberhard, D.,Joberty, G.,Lind, K.E.,Locke, K.,Maller, C.,Martinod, K.,Patten, C.,Polyakova, O.,Rise, C.E.,Rudiger, M.,Sheppard, R.J.,Slade, D.J.,Thomas, P.,Thorpe, J.,Yao, G.,Drewes, G.,Wagner, D.D.,Thompson, P.R.,Prinjha, R.K.,Wilson, D.M. Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation. Nat.Chem.Biol., 11:189-191, 2015 Cited by PubMed: 25622091DOI: 10.1038/nchembio.1735 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.29 Å) |
Structure validation
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