4X6S
Grb7 SH2 domain with phosphotyrosine mimetic inhibitor peptide
Summary for 4X6S
Entry DOI | 10.2210/pdb4x6s/pdb |
Descriptor | Growth factor receptor-bound protein 7, Phosphotyrosine mimetic inhibitor peptide G7-TEM1 (3 entities in total) |
Functional Keywords | src homology domain, inhibitor, phosphotyrosine binding pocket, signaling protein-inhibitor complex, signaling protein/inhibitor |
Biological source | Homo sapiens (Human) More |
Cellular location | Cytoplasm: Q14451 |
Total number of polymer chains | 4 |
Total formula weight | 28080.05 |
Authors | Watson, G.M.,Panjikar, S.,Wilce, M.C.,Wilce, J.A. (deposition date: 2014-12-09, release date: 2015-09-23, Last modification date: 2015-10-28) |
Primary citation | Watson, G.M.,Gunzburg, M.J.,Ambaye, N.D.,Lucas, W.A.,Traore, D.A.,Kulkarni, K.,Cergol, K.M.,Payne, R.J.,Panjikar, S.,Pero, S.C.,Perlmutter, P.,Wilce, M.C.,Wilce, J.A. Cyclic Peptides Incorporating Phosphotyrosine Mimetics as Potent and Specific Inhibitors of the Grb7 Breast Cancer Target. J.Med.Chem., 58:7707-7718, 2015 Cited by PubMed: 26359549DOI: 10.1021/acs.jmedchem.5b00609 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.55 Å) |
Structure validation
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