4WJ5

Structure of HLA-A2 in complex with an altered peptide ligands based on Mart-1 variant epitope

Summary for 4WJ5

• Entry DOI: 10.2210/pdb4wj5/pdb
• Descriptor: HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, Melanoma antigen recognized by T-cells 1, ... (5 entities in total)
• Functional Keywords: antigen presentation, major histocompatibility complex, hla-a2 antigen, altered peptide ligand, immune system
• Biological source: Homo sapiens (Human); More
• Cellular location: Membrane; Single-pass type I membrane protein: P01892; Secreted : P61769; Endoplasmic reticulum membrane; Single-pass type III membrane protein: Q16655
• Total number of polymer chains: 6
• Total formula weight: 90634.70

Authors

Celie, P.H.N.,Rodenko, B.,Ovaa, H. (deposition date: 2014-09-29, release date: 2014-10-29, Last modification date: 2024-01-10)

• Primary citation: Hoppes, R.,Oostvogels, R.,Luimstra, J.J.,Wals, K.,Toebes, M.,Bies, L.,Ekkebus, R.,Rijal, P.,Celie, P.H.,Huang, J.H.,Emmelot, M.E.,Spaapen, R.M.,Lokhorst, H.,Schumacher, T.N.,Mutis, T.,Rodenko, B.,Ovaa, H.; Altered Peptide Ligands Revisited: Vaccine Design through Chemically Modified HLA-A2-Restricted T Cell Epitopes.; J Immunol., 193:4803-4813, 2014; PubMed: 25311806; DOI: 10.4049/jimmunol.1400800

Experimental method

X-RAY DIFFRACTION (1.65 Å)