4WJ5
Structure of HLA-A2 in complex with an altered peptide ligands based on Mart-1 variant epitope
Summary for 4WJ5
Entry DOI | 10.2210/pdb4wj5/pdb |
Descriptor | HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, Melanoma antigen recognized by T-cells 1, ... (5 entities in total) |
Functional Keywords | antigen presentation, major histocompatibility complex, hla-a2 antigen, altered peptide ligand, immune system |
Biological source | Homo sapiens (Human) More |
Cellular location | Membrane; Single-pass type I membrane protein: P01892 Secreted : P61769 Endoplasmic reticulum membrane; Single-pass type III membrane protein: Q16655 |
Total number of polymer chains | 6 |
Total formula weight | 90634.70 |
Authors | Celie, P.H.N.,Rodenko, B.,Ovaa, H. (deposition date: 2014-09-29, release date: 2014-10-29, Last modification date: 2024-01-10) |
Primary citation | Hoppes, R.,Oostvogels, R.,Luimstra, J.J.,Wals, K.,Toebes, M.,Bies, L.,Ekkebus, R.,Rijal, P.,Celie, P.H.,Huang, J.H.,Emmelot, M.E.,Spaapen, R.M.,Lokhorst, H.,Schumacher, T.N.,Mutis, T.,Rodenko, B.,Ovaa, H. Altered Peptide Ligands Revisited: Vaccine Design through Chemically Modified HLA-A2-Restricted T Cell Epitopes. J Immunol., 193:4803-4813, 2014 Cited by PubMed: 25311806DOI: 10.4049/jimmunol.1400800 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.65 Å) |
Structure validation
Download full validation report