4WH8
Crystal Structure of HCV NS3/4A protease in complex with an Asunaprevir P1-P3 macrocyclic analog.
Summary for 4WH8
Entry DOI | 10.2210/pdb4wh8/pdb |
Related | 4WF8 4WH6 |
Descriptor | Genome polyprotein, tert-butyl {(2R,4S,6S,12Z,13aS,14aR,16aS)-2-[(7-chloro-4-methoxyisoquinolin-1-yl)oxy]-14a-[(cyclopropanesulfonyl)carbamoyl]-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin-6-yl}carbamate, SULFATE ION, ... (5 entities in total) |
Functional Keywords | hcv drug resistance, protease-inhibitor complex, asunaprevir, macrocycle, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Hepatitis C virus subtype 1a |
Total number of polymer chains | 2 |
Total formula weight | 43879.29 |
Authors | Soumana, D.I.,Ali, A.,Schiffer, C.A. (deposition date: 2014-09-20, release date: 2014-10-15, Last modification date: 2024-05-22) |
Primary citation | Soumana, D.I.,Ali, A.,Schiffer, C.A. Structural Analysis of Asunaprevir Resistance in HCV NS3/4A Protease. Acs Chem.Biol., 9:2485-2490, 2014 Cited by PubMed: 25243902DOI: 10.1021/cb5006118 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.703 Å) |
Structure validation
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