4WDI

Weak TCR binding to an unstable insulin epitope drives type 1 diabetes

Summary for 4WDI

• Entry DOI: 10.2210/pdb4wdi/pdb
• Related: 4WDJ 4WDK 4WDL
• Descriptor: H-2 class I histocompatibility antigen, K-D alpha chain, Beta-2-microglobulin, Insulin, ... (6 entities in total)
• Functional Keywords: immunoglobulin, h-2kd, type 1 diabetes, immune system
• Biological source: Mus musculus (House Mouse); More
• Cellular location: Secreted : P61769 P01308
• Total number of polymer chains: 6
• Total formula weight: 90931.44

Authors

Rizkallah, P.J.,Cole, D.K. (deposition date: 2014-09-08, release date: 2015-06-24, Last modification date: 2015-07-01)

• Primary citation: Motozono, C.,Pearson, J.A.,De Leenheer, E.,Rizkallah, P.J.,Beck, K.,Trimby, A.,Sewell, A.K.,Wong, F.S.,Cole, D.K.; Distortion of the Major Histocompatibility Complex Class I Binding Groove to Accommodate an Insulin-derived 10-Mer Peptide.; J.Biol.Chem., 290:18924-18933, 2015; PubMed: 26085090; DOI: 10.1074/jbc.M114.622522

Experimental method

X-RAY DIFFRACTION (2.313 Å)