4WDI
Weak TCR binding to an unstable insulin epitope drives type 1 diabetes
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, D | H-2 class I histocompatibility antigen, K-D alpha chain | polymer | 277 | 32353.0 | 2 | Pfam (PF00129) Pfam (PF07654) UniProt (by SIFTS) (P01902) In PDB | Mus musculus (House Mouse) | H-2K(D) |
| 2 | B, E | Beta-2-microglobulin | polymer | 100 | 11879.4 | 2 | UniProt (P61769) Pfam (PF07654) In PDB | Homo sapiens (Human) | |
| 3 | C, F | Insulin | polymer | 9 | 1010.2 | 2 | UniProt (P01308) In PDB | Homo sapiens (Human) | |
| 4 | A | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 5 | A, B, E | SULFATE ION | non-polymer | 96.1 | 4 | Chemie (SO4) | |||
| 6 | water | water | 18.0 | 160 | Chemie (HOH) |
Sequence modifications
B, E: 1 - 99 (UniProt: P61769)
| PDB | External Database | Details |
|---|---|---|
| Met 0 | - | initiating methionine |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 90485.1 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 446.3 | |
| All* | Total formula weight | 90931.4 |
