4W9X

Crystal Structure of BMP-2-inducible kinase in complex with baricitinib

Summary for 4W9X

• Entry DOI: 10.2210/pdb4w9x/pdb
• Related: 4W9W
• Descriptor: BMP-2-inducible protein kinase, 1,2-ETHANEDIOL, Baricitinib, ... (4 entities in total)
• Functional Keywords: kinase, small-molecule, catalytic domain, protein binding, inhibitor, structural genomics, structural genomics consortium, sgc, transferase
• Biological source: Homo sapiens (Human)
• Cellular location: Nucleus : Q9NSY1
• Total number of polymer chains: 1
• Total formula weight: 35286.59

Authors

Sorrell, F.J.,Elkins, J.M.,Krojer, T.,Williams, E.,Savitsky, P.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2014-08-28, release date: 2014-09-10, Last modification date: 2018-01-24)

• Primary citation: Sorrell, F.J.,Szklarz, M.,Abdul Azeez, K.R.,Elkins, J.M.,Knapp, S.; Family-wide Structural Analysis of Human Numb-Associated Protein Kinases.; Structure, 24:401-411, 2016; PubMed: 26853940; DOI: 10.1016/j.str.2015.12.015

Experimental method

X-RAY DIFFRACTION (2.14 Å)