4W9X
Crystal Structure of BMP-2-inducible kinase in complex with baricitinib
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | BMP-2-inducible protein kinase | polymer | 310 | 34791.0 | 1 | UniProt (Q9NSY1) Pfam (PF00069) | Homo sapiens (Human) | BIKe |
| 2 | B, C (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | |||
| 3 | D (A) | Baricitinib | non-polymer | 371.4 | 1 | Chemie (3JW) | |||
| 4 | E (A) | water | water | 18.0 | 129 | Chemie (HOH) |
Sequence modifications
A: 38 - 345 (UniProt: Q9NSY1)
| PDB | External Database | Details |
|---|---|---|
| Ser 36 | - | expression tag |
| Met 37 | - | expression tag |
| Ala 320 | Lys 320 | engineered mutation |
| Ala 321 | Lys 321 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 34791.0 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 495.6 | |
| All* | Total formula weight | 35286.6 |
