4W9H

pVHL:EloB:EloC in complex with (2S,4R)-1-((S)-2-acetamido-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (ligand 7)

Summary for 4W9H

Entry DOI	10.2210/pdb4w9h/pdb
Descriptor	Transcription elongation factor B polypeptide 2, Transcription elongation factor B polypeptide 1, Von Hippel-Lindau disease tumor suppressor, ... (6 entities in total)
Functional Keywords	protein complex, ubiquitin ligase, hypoxia inducible factor, ligase
Biological source	Homo sapiens (Human) More
Cellular location	Nucleus : Q15370 Q15369 Q15369 Isoform 1: Cytoplasm. Isoform 3: Cytoplasm: P40337
Total number of polymer chains	12
Total formula weight	169047.41
Authors	Gadd, M.S.,Soares, P.,Galdeano, C.,van Molle, I.,Ciulli, A. (deposition date: 2014-08-27, release date: 2014-09-10, Last modification date: 2024-01-10)
Primary citation	Galdeano, C.,Gadd, M.S.,Soares, P.,Scaffidi, S.,Van Molle, I.,Birced, I.,Hewitt, S.,Dias, D.M.,Ciulli, A. Structure-Guided Design and Optimization of Small Molecules Targeting the Protein-Protein Interaction between the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase and the Hypoxia Inducible Factor (HIF) Alpha Subunit with in Vitro Nanomolar Affinities. J.Med.Chem., 57:8657-8663, 2014 Cited by PubMed: 25166285 DOI: 10.1021/jm5011258 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation