4W9H
pVHL:EloB:EloC in complex with (2S,4R)-1-((S)-2-acetamido-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (ligand 7)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, D, G, J (A, D, G, J) | Transcription elongation factor B polypeptide 2 | polymer | 104 | 11956.4 | 4 | UniProt (Q15370) Pfam (PF00240) | Homo sapiens (Human) | Elongin 18 kDa subunit,Elongin-B,EloB,RNA polymerase II transcription factor SIII subunit B,SIII p18 |
| 2 | B, E (B, E) | Transcription elongation factor B polypeptide 1 | polymer | 97 | 11078.6 | 2 | UniProt (Q15369) Pfam (PF03931) | Homo sapiens (Human) | Elongin 15 kDa subunit,Elongin-C,EloC,RNA polymerase II transcription factor SIII subunit C,SIII p15 |
| 3 | C, F, I, L (C, F, I, L) | Von Hippel-Lindau disease tumor suppressor | polymer | 162 | 18806.3 | 4 | UniProt (P40337) Pfam (PF01847) Pfam (PF17211) | Homo sapiens (Human) | Protein G7,pVHL |
| 4 | H, K (H, K) | Transcription elongation factor B polypeptide 1 | polymer | 97 | 10974.6 | 2 | UniProt (Q15369) Pfam (PF03931) | Homo sapiens (Human) | Elongin 15 kDa subunit,Elongin-C,EloC,RNA polymerase II transcription factor SIII subunit C,SIII p15 |
| 5 | M, N, O, P (C, F, I, L) | N-acetyl-3-methyl-L-valyl-(4R)-4-hydroxy-N-[4-(4-methyl-1,3-thiazol-5-yl)benzyl]-L-prolinamide | non-polymer | 472.6 | 4 | Chemie (3JF) PubChem (77232228) PubChem (123336421) PubChem (102341125) PubChem (135173698) PubChem (135382158) PubChem (158243437) PubChem (166540401) PubChem (166735255) PubChem (168252964) PubChem (169841967) PubChem (171604510) | |||
| 6 | AA, BA, Q, R, S... (K, L, A, B, C...) | water | water | 18.0 | 575 | Chemie (HOH) |
Sequence modifications
B, E: 17 - 112 (UniProt: Q15369)
C, F, I, L: 54 - 213 (UniProt: P40337)
H, K: 17 - 112 (UniProt: Q15369)
| PDB | External Database | Details |
|---|---|---|
| Met 16 | - | initiating methionine |
| PDB | External Database | Details |
|---|---|---|
| Gly 52 | - | expression tag |
| Ser 53 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met 16 | - | initiating methionine |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 167157.0 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1890.4 | |
| All* | Total formula weight | 169047.4 |
